Protein Details: Transient receptor potential cation channel subfamily V member 2

Protein ID

ICDB_Pro_1687

Protein Name

Transient receptor potential cation channel subfamily V member 2

Gene Name

Trpv2 Grc

Organism

Mus musculus (Mouse)

Length

756 amino acids

AlphaFoldDB

AF-Q9WTR1-F1-model_v4.pdb

Function

Calcium-permeable, non-selective cation channel with an outward rectification. Seems to be regulated, at least in part, by IGF-I, PDGF and neuropeptide head activator. May transduce physical stimuli in mast cells. Activated by temperatures higher than 52 degrees Celsius; is not activated by vanilloids and acidic pH

Sequence

MTSASNPPAFRLETSDGDEEGSAEVNKGKNEPPPMESPFQGEDRNFSPQIKVNLNYRKGLGPSQQDPNRFDRDRLFSVVSRGVPEELTGLLEYLRRTSKYLTDSAYTEGSTGKTCLMKAVLNLQDGVNACILPLLQIDRDSGNPQPLVNAQCTDEFYRGHSALHIAIEKRSLWCVKLLVENGANVHIRACGRFFQKHQGTCFYFGELPLSLAACTKQWDVVTYLLENPHQPASLEATDSLGNTVLHALVMIADNSPENSALVIHMYDSLLQMGARLCPTVQLEDICNHQGLTPLKLAAKEGKIEIFRHILQREFSGLYQPLSRKFTEWCYGPVRVSLYDLSSVDSWEKNSVLEIIAFHCKSPHRHRMVVLEPLNKLLQEKWDRLIPRFFFNFACYLVYMIIFTIVAYHQPSLEQPAIPSSKATFGDSMLLLGHILILLGGIYLLLGQLWYFWRRRLFIWISFMDSYFEILFLVQALLTVLSQVLRFVETEWYLPLLVSSLVLGWLNLLYYTRGFQHTGIYSVMIQKVILRDLLRFLLVYLVFLFGFAVALVSLSREARSPKAPEDSNTTVTEKPTLGQEEEPVPYGGILDASLELFKFTIGMGELAFQEQLRFRGVVLLLLLAYVLLTYVLLLNMLIALMSETVNSVATDSWSIWKLQKAISVLEMENGYWWCRRKRHRAGRLLKVGTKGDGIPDERWCFRVEEVNWAAWEKTLPTLSEDPSGAGITGYKKNPTSKPGKNSASEEDHLPLQVLQSH

PDB Structures

7XEM 7XEO 7XER 7XEU 7XEV 7XEW 7YEP

Ligand Binding

1. DICL_CP

2. DICL_Pep

Binding Site

Disease

Location

DOI ID

10.1038/11086; 10.1126/science.1112014; 10.1371/journal.pbio.1000112; 10.1101/gr.2596504; 10.1242/jcs.114.20.3599; 10.1016/j.immuni.2008.11.006; 10.1016/j.cell.2010.12.001

RefSeq

NP_035836.2; XP_006533228.1; XP_011247273.1